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Manach et al., 1997 )

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Excessive secretion of corticotropin-releasing hormones (CRH) in patients with depression increases CRH in the blood, cerebrospinal fluid, and metabolites, which downregulate the CRH receptor and cause the loss of the action site of excessive secretion of CRH, resulting in a vicious cycle of increasing CRH in the body and eventually producing depressive symptoms [107]